Two Fatal Cases Involving Cardiovascular Drugs Diltiazem and Amlodipine

Non-Fatal Amlodipine and Insulin Overdose in an Elderly Person

Comparing fatal cases involving U-47700.

U-47700 (3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]N-methylbenzamide) is a novel compound with opioid properties, developed by Upjohn in the 1970s and derived from the earlier opioid analgesic AH-7921 (3,4-dichloro-N{[1-(dimethylamino)-cyclohexyl]methyl}benzamide) [1]. U-47700 is a structural isomer of AH-7921 [2]. AH-7921, which possesses the same potency as morphine, was first identified in...

Fatal diltiazem overdose: report of four cases and review of the literature.

Four fatal cases of diltiazem overdose are described and compared with previously published cases. Clinical sequelae include all grades of heart block, hypotension and ultimately death. Management includes gastric lavage and oral administration of activated charcoal at presentation. Further symptomatic treatment with inotropic agents and temporary cardiac pacing may be required. If these measur...

Two cases of fatal zopiclone overdose.

Two cases of death due to the ingestion of zopiclone are presented. Quantitative determinations of zopiclone yielded 1.4-3.9 mg/L in the blood, 0.81 and 8.7 mg/kg in the liver, and 13.5 and 133 mg in the stomach contents. Drug concentrations were interpreted relative to the case findings, published data, and a limited evaluation of therapeutic concentrations found in two cases of therapeutic zo...

Two fatal cases of septicaemia due to

Langford and Hansen (1954) have suggested that the genus Erysipelothrix possesses a single species Erysipelothrix insidiosa and that subdivision into further species is not justified; following their terminology E. insidiosa and E. rhusiopathiae in this account are considered synonymous. Erysipelothrix rhusiopathiae is recognized as the pathogen causing the skin lesions of human erysipeloid. Th...